Urbanization and climate change are two major challenges of the 21st century, and the effects of climate change, combined with the urbanization of coastal areas, increase the frequency of coastal flooding and the area exposed to it, resulting in increased risk of flooding and larger numbers of people and properties being vulnerable. An urban growth modeling system was used to simulate future growth scenarios along the coast of the Vendée region in western France, and the potential exposure to flooding with each scenario was evaluated. The model used was an Artificial Neural Network combined with a Markov Chain, using data obtained by the remote sensing and geographic information system techniques to predict three future urban growth scenarios: business as usual, environmental protection, and strategic urban planning. High-risk flood areas and future sea level projections from the Sixth Assessment Report of the Intergovernmental Panel on Climate Change were then used to assess future flood risk under each growth scenario in the study area. According to the results, the different growth scenarios are associated with different development patterns, and the strategic urban planning scenario significantly reduces the risk of flooding compared to the other two scenarios. However, the rise in sea level considerably expands the areas vulnerable to flooding. Finally, the methodology adopted can be used to prepare for the impact of climate change and develop strategies to mitigate the risk of flooding in the future.