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Article Dans Une Revue Journal of Nutrition, Health & Aging Année : 2024

Vitamin D and behavioral disorders in older adults : results from the CLIP study

Résumé

Objectives : Vitamin D is involved in brain health and function. Our objective was to determine whether vitamin D deficiency was associated with behavioral disorders in geriatric patients. Design: The observational cross-sectional CLIP (Cognition and LIPophilic vitamins) study. The report followed the STROBE tatement. Setting : Geriatric acute care unit in a tertiary university hospital in France for 3 months at the end of winter and beginning of spring. Participants : 272 patients 65 years consecutively hospitalized or seen in consultation. Measurements: Participants were separated into two groups according to vitamin D deficiency (i.e., serum 25-hydroxyvitamin D ≤25 nmol/L). Behavior was assessed using the reduced version of the Neuropsychiatric Inventory Scale (NPI-R) score and subscores. Age, sex, BMI, education level, comorbidities, MMSE and GDS scores, use psychoactive drugs and vitamin D supplements, and serum concentrations of calcium, parathyroid hormone, TSH and estimated glomerular filtration rate (eGFR) were used as potential confounders. Results : Participants with vitamin D deficiency (n = 78) had similar NPI-R score (17.4 ± 20.3 versus 17.2 ± 16.1, p = 0.92) but higher (i.e., worse) subscore of agitation and aggressiveness (2.0 ± 3.3 versus 1.2 ± 2.4, p = 0.02) and higher (i.e., worse) subscore of disinhibition (0.99 2.98 versus 0.38 1.42, p = 0.02) than those without vitamin D deficiency (n = 194). In multiple linear regressions, vitamin D deficiency was inversely associated with the subscore of agitation and aggressiveness (b = 1.37, p = 0.005) and with the subscore of disinhibition (b = 0.96, p = 0.008). Conclusion : Vitamin D deficiency was associated with more severe subscores of agitation and aggressiveness and of disinhibition among older adults. This provides a scientific basis to test the efficacy of vitamin D supplementation on behavioral disorders in older patients with vitamin D deficiency.

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Psychologie
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hal-04586440 , version 1 (24-05-2024)

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Lucie Gilbert, Alexis Bourgeais, Spyridon N Karras, Duygu Gezen-Ak, Erdinç Dursun, et al.. Vitamin D and behavioral disorders in older adults : results from the CLIP study. Journal of Nutrition, Health & Aging, 2024, 28 (4), pp.100205. ⟨10.1016/j.jnha.2024.100205⟩. ⟨hal-04586440⟩
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