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authIdHal_s : gildas-loussouarn
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hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state

Olfat A. Malak , Zeineb Es-Salah-Lamoureux , Gildas Loussouarn
Scientific Reports, 2017, 7 (1), pp.113. ⟨10.1038/s41598-017-00155-2⟩
Journal articles hal-01832145v1
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Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome

Mariam Jouni , Karim Si-Tayeb , Zeineb Es-Salah-Lamoureux , Xenia Latypova , Benoite Champon , et al.
Journal of the American Heart Association, 2015, pp.e002159. ⟨10.1161/JAHA.115.002159⟩
Journal articles inserm-01199430v1
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Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome

Maria Karlova , Denis Abramochkin , Ksenia Pustovit , Tatiana Nesterova , Valery Novoseletsky , et al.
International Journal of Molecular Sciences, 2022, 23 (14), pp.7953. ⟨10.3390/ijms23147953⟩
Journal articles hal-03797267v1
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Predicting hERG repolarization power at 37°C from recordings at room temperature

Barbara B R Oliveira‐mendes , Malak Alameh , Jérôme Montnach , Béatrice Ollivier , Solène Gibaud , et al.
Clinical and Translational Medicine, 2023, 13 (5), ⟨10.1002/ctm2.1266⟩
Journal articles hal-04109461v1
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The Integrative Approach to Study of the Structure and Functions of Cardiac Voltage-Dependent Ion Channels

Juila G Kacher , Maria G Karlova , Grigory S Glukhov , Han Zhang , Elena V Zaklyazminskaya , et al.
Preprints, Working Papers, ... hal-03350105v1
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Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome

Jérôme Montnach , Franck Chizelle , Nadjet Belbachir , Claire Castro , Linwei Li , et al.
Journal of Molecular and Cellular Cardiology, 2018, 123, pp.13 - 25. ⟨10.1016/j.yjmcc.2018.08.019⟩
Journal articles hal-01900579v1

KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines.

Julien Piron , Frank S Choveau , Mohammed Yassine Amarouch , Nicolas Rodriguez , Flavien Charpentier , et al.
The Journal of Physiology, 2010, 588 ((Pt 18)), pp.3471-83. ⟨10.1113/jphysiol.2010.195313⟩
Journal articles hal-00651470v1

Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains

Cristina Moreno , Alicia de La Cruz , Anna Oliveras , Sanjay R. Kharche , Miriam Guizy , et al.
Cardiovascular Research, 2015, Equipe 1, 105 (2), pp.223--232. ⟨10.1093/cvr/cvu250⟩
Journal articles hal-01830579v1
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Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction

Zeina R Al Sayed , Robin Canac , Bastien Cimarosti , Carine Bonnard , Jean-Baptiste Gourraud , et al.
Cardiovascular Research, 2021, 117 (9), pp.2092-2107. ⟨10.1093/cvr/cvaa259⟩
Journal articles inserm-02934863v2
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Modeling sudden cardiac death risks factors in COVID-19 patients -the hydroxychloroquine and azithromycin case

Jérôme Montnach , Isabelle Baró , Flavien Charpentier , Michel de Waard , Gildas Loussouarn
Journal articles hal-03349858v1
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Editorial: Molecular Mechanisms of Voltage-Gating in Ion Channels

Gildas Loussouarn , Mounir Tarek
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.768153⟩
Journal articles hal-03348830v1
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SARS-CoV-2 E and 3a proteins are inducers of pannexin currents

Barbara Oliveira Mendes , Malak Alameh , Beatrice Ollivier , Jerome Montnach , Nicolas Bidere , et al.
Preprints, Working Papers, ... hal-03823805v1
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Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

Jérôme Montnach , Maxime Lorenzini , Adrien Lesage , Isabelle Simon , Sébastien Nicolas , et al.
Scientific Reports, 2021, ⟨10.1038/s41598-021-82077-8⟩
Journal articles hal-03160824v1
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Dysfunction of the Voltage-Gated K+ Channel beta 2 Subunit in a Familial Case of Brugada Syndrome

Vincent Portero , Solena Le Scouarnec , Zeineb Es-Salah-Lamoureux , Sophie Burel , Jean-Baptiste Gourraud , et al.
Journal of the American Heart Association, 2016, 5 (6), pp.e003122. ⟨10.1161/JAHA.115.003122⟩
Journal articles hal-01414464v1

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation

F. C. Coyan , F. Abderemane-Ali , M. Y. Amarouch , J. Piron , J. Mordel , et al.
PLoS ONE, 2014, 9 (3), pp.e93255. ⟨10.1371/journal.pone.0093255⟩
Journal articles hal-02363771v1

Studying Kv Channels Function using Computational Methods

Audrey Deyawe , Marina A. Kasimova , Lucie Delemotte , Gildas Loussouarn , Mounir Tarek
Methods in Molecular Biology, 2018, Equipe IIa, 1684, pp.321--341. ⟨10.1007/978-1-4939-7362-0_24⟩
Journal articles hal-01833334v1
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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism

Olfat Malak , Fayal Abderemane-Ali , Yue Wei , Fabien C Coyan , Gilyane Pontus , et al.
Scientific Reports, 2020, 10, pp.5852. ⟨10.1038/s41598-020-62615-6⟩
Journal articles hal-02531094v1
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Multifocal Ectopic Purkinje-Related Premature Contractions: A New SCN5A-Related Cardiac Channelopathy.

Gabriel Laurent , Samuel Saal , Mohamed Yassine Amarouch , Delphine M. Béziau , Roos F. J. Marsman , et al.
Journal of the American College of Cardiology, 2012, 60 (2), pp.144-56. ⟨10.1016/j.jacc.2012.02.052⟩
Journal articles inserm-00719034v1
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Detergent-free solubilization of human Kv channels expressed in mammalian cells

M G Karlova , N Voskoboynikova , G S Gluhov , D Abramochkin , O A Malak , et al.
Chemistry and Physics of Lipids, 2019, ⟨10.1016/j.chemphyslip.2019.01.013⟩
Journal articles hal-02109357v1
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Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism

Olfat A Malak , Grigory S Gluhov , Anastasia V Grizel , Kseniya S Kudryashova , Olga Sokolova , et al.
Journal of Biological Chemistry, 2019, ⟨10.1074/jbc.RA119.007626⟩
Journal articles hal-02104954v1

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

Frank S Choveau , Nicolas Rodriguez , Fayal Abderemane Ali , Alain J Labro , Thierry Rose , et al.
Journal of Biological Chemistry, 2011, 286 (1), pp.707-16. ⟨10.1074/jbc.M110.146324⟩
Journal articles hal-00642776v1

Building Atomic Models of the Ion Channels Based on Low Resolution Electron Microscopy Maps and Homology Modeling

Valery Novoseletsky , Olfat A. Malak , Gildas Loussouarn , Olga S. Sokolova
Methods in Molecular Biology, 2018, Equipe IIa, 1684, pp.305--319. ⟨10.1007/978-1-4939-7362-0_23⟩
Journal articles hal-01833327v1
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Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

Gildas Loussouarn , Damien Sternberg , Sophie Nicole , Céline Marionneau , Francoise Le Bouffant , et al.
Frontiers in Pharmacology, 2016, 6, pp.314. ⟨10.3389/fphar.2015.00314⟩
Journal articles hal-01270688v1
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HIV-Tat induces a decrease in I Kr and I Ks via reduction in phosphatidylinositol-(4,5)-bisphosphate availability

Zeineb Es-Salah-Lamoureux , Mariam Jouni , Nadjet Belbachir , Zeina Reda , Al Sayed , et al.
Journal of Molecular and Cellular Cardiology, 2016, [Epub ahead of print]. ⟨10.1016/j.yjmcc.2016.08.022⟩
Journal articles inserm-01360585v1

C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation

Sophie Burel , Fabien C. Coyan , Maxime Lorenzini , Matthew R. Meyer , Cheryl F. Lichti , et al.
Journal of Biological Chemistry, 2017, Equipe IIa, 292 (42), pp.17431--17448. ⟨10.1074/jbc.M117.787788⟩
Journal articles hal-01832134v1

Phosphatidylinositol (4,5)-bisphosphate-mediated pathophysiological effect of HIV-1 Tat protein

Bruno Beaumelle , Petra Toth , Olfat Malak , Christophe Chopard , Gildas Loussouarn , et al.
Biochimie, 2017, 141, pp.80-85. ⟨10.1016/j.biochi.2017.05.014⟩
Journal articles hal-02137771v1
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Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Stephan de Waard , Jérôme Montnach , Barbara Ribeiro , Sébastien Nicolas , Virginie Forest , et al.
International Journal of Molecular Sciences, 2020, 2020, ⟨10.3390/ijms21197167⟩
Journal articles hal-02951542v1

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel.

Nicolas Rodriguez , Mohamed Yassine Amarouch , Jérôme Montnach , Julien Piron , Alain J Labro , et al.
Biophysical Journal, 2010, 99 ((4)), pp.1110-8. ⟨10.1016/j.bpj.2010.06.013⟩
Journal articles hal-00651490v1