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hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state
Olfat A. Malak
,
Zeineb Es-Salah-Lamoureux
,
Gildas Loussouarn
Journal articles
hal-01832145v1
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Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome
Mariam Jouni
,
Karim Si-Tayeb
,
Zeineb Es-Salah-Lamoureux
,
Xenia Latypova
,
Benoite Champon
,
et al.
Journal articles
inserm-01199430v1
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Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome
Maria Karlova
,
Denis Abramochkin
,
Ksenia Pustovit
,
Tatiana Nesterova
,
Valery Novoseletsky
,
et al.
Journal articles
hal-03797267v1
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Predicting hERG repolarization power at 37°C from recordings at room temperature
Barbara B R Oliveira‐mendes
,
Malak Alameh
,
Jérôme Montnach
,
Béatrice Ollivier
,
Solène Gibaud
,
et al.
Journal articles
hal-04109461v1
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The Integrative Approach to Study of the Structure and Functions of Cardiac Voltage-Dependent Ion Channels
Juila G Kacher
,
Maria G Karlova
,
Grigory S Glukhov
,
Han Zhang
,
Elena V Zaklyazminskaya
,
et al.
2021
Preprints, Working Papers, ...
hal-03350105v1
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Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome
Jérôme Montnach
,
Franck Chizelle
,
Nadjet Belbachir
,
Claire Castro
,
Linwei Li
,
et al.
Journal articles
hal-01900579v1
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KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines.
Julien Piron
,
Frank S Choveau
,
Mohammed Yassine Amarouch
,
Nicolas Rodriguez
,
Flavien Charpentier
,
et al.
Journal articles
hal-00651470v1
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Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains
Cristina Moreno
,
Alicia de La Cruz
,
Anna Oliveras
,
Sanjay R. Kharche
,
Miriam Guizy
,
et al.
Journal articles
hal-01830579v1
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Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction
Zeina R Al Sayed
,
Robin Canac
,
Bastien Cimarosti
,
Carine Bonnard
,
Jean-Baptiste Gourraud
,
et al.
Journal articles
inserm-02934863v2
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Modeling sudden cardiac death risks factors in COVID-19 patients -the hydroxychloroquine and azithromycin case
Jérôme Montnach
,
Isabelle Baró
,
Flavien Charpentier
,
Michel de Waard
,
Gildas Loussouarn
Journal articles
hal-03349858v1
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Editorial: Molecular Mechanisms of Voltage-Gating in Ion Channels
Gildas Loussouarn
,
Mounir Tarek
Journal articles
hal-03348830v1
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SARS-CoV-2 E and 3a proteins are inducers of pannexin currents
Barbara Oliveira Mendes
,
Malak Alameh
,
Beatrice Ollivier
,
Jerome Montnach
,
Nicolas Bidere
,
et al.
2022
Preprints, Working Papers, ...
hal-03823805v1
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Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp
Jérôme Montnach
,
Maxime Lorenzini
,
Adrien Lesage
,
Isabelle Simon
,
Sébastien Nicolas
,
et al.
Journal articles
hal-03160824v1
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Dysfunction of the Voltage-Gated K+ Channel beta 2 Subunit in a Familial Case of Brugada Syndrome
Vincent Portero
,
Solena Le Scouarnec
,
Zeineb Es-Salah-Lamoureux
,
Sophie Burel
,
Jean-Baptiste Gourraud
,
et al.
Journal articles
hal-01414464v1
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A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation
F. C. Coyan
,
F. Abderemane-Ali
,
M. Y. Amarouch
,
J. Piron
,
J. Mordel
,
et al.
Journal articles
hal-02363771v1
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Studying Kv Channels Function using Computational Methods
Audrey Deyawe
,
Marina A. Kasimova
,
Lucie Delemotte
,
Gildas Loussouarn
,
Mounir Tarek
Journal articles
hal-01833334v1
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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
Olfat Malak
,
Fayal Abderemane-Ali
,
Yue Wei
,
Fabien C Coyan
,
Gilyane Pontus
,
et al.
Journal articles
hal-02531094v1
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Multifocal Ectopic Purkinje-Related Premature Contractions: A New SCN5A-Related Cardiac Channelopathy.
Gabriel Laurent
,
Samuel Saal
,
Mohamed Yassine Amarouch
,
Delphine M. Béziau
,
Roos F. J. Marsman
,
et al.
Journal articles
inserm-00719034v1
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Detergent-free solubilization of human Kv channels expressed in mammalian cells
M G Karlova
,
N Voskoboynikova
,
G S Gluhov
,
D Abramochkin
,
O A Malak
,
et al.
Journal articles
hal-02109357v1
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Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism
Olfat A Malak
,
Grigory S Gluhov
,
Anastasia V Grizel
,
Kseniya S Kudryashova
,
Olga Sokolova
,
et al.
Journal articles
hal-02104954v1
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KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.
Frank S Choveau
,
Nicolas Rodriguez
,
Fayal Abderemane Ali
,
Alain J Labro
,
Thierry Rose
,
et al.
Journal articles
hal-00642776v1
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Building Atomic Models of the Ion Channels Based on Low Resolution Electron Microscopy Maps and Homology Modeling
Valery Novoseletsky
,
Olfat A. Malak
,
Gildas Loussouarn
,
Olga S. Sokolova
Journal articles
hal-01833327v1
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Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison
Gildas Loussouarn
,
Damien Sternberg
,
Sophie Nicole
,
Céline Marionneau
,
Francoise Le Bouffant
,
et al.
Journal articles
hal-01270688v1
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HIV-Tat induces a decrease in I Kr and I Ks via reduction in phosphatidylinositol-(4,5)-bisphosphate availability
Zeineb Es-Salah-Lamoureux
,
Mariam Jouni
,
Nadjet Belbachir
,
Zeina Reda
,
Al Sayed
,
et al.
Journal articles
inserm-01360585v1
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C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation
Sophie Burel
,
Fabien C. Coyan
,
Maxime Lorenzini
,
Matthew R. Meyer
,
Cheryl F. Lichti
,
et al.
Journal articles
hal-01832134v1
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Phosphatidylinositol (4,5)-bisphosphate-mediated pathophysiological effect of HIV-1 Tat protein
Bruno Beaumelle
,
Petra Toth
,
Olfat Malak
,
Christophe Chopard
,
Gildas Loussouarn
,
et al.
Journal articles
hal-02137771v1
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Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells
Stephan de Waard
,
Jérôme Montnach
,
Barbara Ribeiro
,
Sébastien Nicolas
,
Virginie Forest
,
et al.
Journal articles
hal-02951542v1
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Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel.
Nicolas Rodriguez
,
Mohamed Yassine Amarouch
,
Jérôme Montnach
,
Julien Piron
,
Alain J Labro
,
et al.
Journal articles
hal-00651490v1
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