Thomas, C, Delfour-Peyrethon, R, Dorel, S, and Hanon, C. Positive effects of pre-exercise metabolic alkalosis on perceived exertion and post-exercise squat jump performance in world-class cyclists. J Strength Cond Res 36(9): 2602–2609, 2022—This study aimed to determine the effects of pre-exercise alkalosis in world-class cyclists on their general (rate of perceived exertion [RPE]) and local (category-ratio scale [CR10]) perceived rates of exertion and acid-base status during 2 types of training sessions. Eight world-class cyclists ingested either sodium bicarbonate (BIC) or a placebo (PLA) in a double-blind and randomized order before performing 4 × 1,000 m constant-power sprints (CP) or 3 × 500 m all-out sprints (AO), with 20 minutes of recovery time between each session. For AO, the performance was assessed through the cycling sprint velocity and a squat jump test during recovery. During both tests, RPE, CR10, and acid-base status were measured. Sodium bicarbonate ingestion was effective in inducing pre-exercise alkalosis, compared with a PLA ( p < 0.05). During CP, performance and RPE were the same for BIC and PLA ( p > 0.05) with no time effect. The CR10 increased for the last sprint in PLA ( p < 0.05) but was attenuated in BIC (BIC: 6 vs. PLA: 8.2; p < 0.05), whereas there was no difference in acid-base status. During AO, RPE and CR10 increased with time, with no BIC effect, whereas blood lactate concentration was different ( p < 0.05). Sodium bicarbonate supplementation had no effect on overall repeated sprints ( p > 0.05). However, world-class athletes responded to BIC with higher squat jump performance than the PLA condition after AO ( p < 0.05). Our results suggest a positive influence of pre-exercise alkalosis in world-class cyclists on local perception of efforts after constant load sprints and an attenuation of muscle power output decline postsprint, as evidenced by improved squat jump performance after all-out cycling effort.