Phase 1 Study of the Combination of Escalated Total Marrow Irradiation Using Helical Tomotherapy and Fixed High-Dose Melphalan (140 mg/m²) Followed by Autologous Stem Cell Transplantation at First Relapse in Multiple Myeloma - Nantes Université
Article Dans Une Revue International Journal of Radiation Oncology, Biology, Physics Année : 2023

Phase 1 Study of the Combination of Escalated Total Marrow Irradiation Using Helical Tomotherapy and Fixed High-Dose Melphalan (140 mg/m²) Followed by Autologous Stem Cell Transplantation at First Relapse in Multiple Myeloma

Résumé

A second intensification is an option at first relapse in multiple myeloma (MM) after more than 36 months of initial remission. Many conditioning regimens have been tested, with or without total body irradiation (TBI). Recently, it was found that TBI could be replaced by total marrow irradiation (TMI) using helical tomotherapy, with promising results.

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Médecine humaine et pathologie

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https://nantes-universite.hal.science/hal-04756135

Soumis le : lundi 28 octobre 2024-11:37:51

Dernière modification le : mercredi 30 octobre 2024-18:08:04

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hal-04756135 , version 1 (28-10-2024)

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Axel Cailleteau, Philippe Maingon, Sylvain Choquet, Rémi Bourdais, Delphine Antoni, et al.. Phase 1 Study of the Combination of Escalated Total Marrow Irradiation Using Helical Tomotherapy and Fixed High-Dose Melphalan (140 mg/m²) Followed by Autologous Stem Cell Transplantation at First Relapse in Multiple Myeloma. International Journal of Radiation Oncology, Biology, Physics, 2023, 115 (3), pp.677-685. ⟨10.1016/j.ijrobp.2022.09.069⟩. ⟨hal-04756135⟩

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