Fluid Mechanics of Mosaic Ciliated Tissues - Nantes Université Access content directly
Journal Articles Physical Review Letters Year : 2021

Fluid Mechanics of Mosaic Ciliated Tissues

Abstract

In tissues as diverse as amphibian skin and the human airway, the cilia that propel fluid are grouped in sparsely distributed multiciliated cells (MCCs). We investigate fluid transport in this "mosaic" architecture, with emphasis on the trade-offs that may have been responsible for its evolutionary selection. Live imaging of MCCs in embryos of the frog Xenopus laevis shows that cilia bundles behave as active vortices that produce a flow field accurately represented by a local force applied to the fluid. A coarse-grained model that self-consistently couples bundles to the ambient flow reveals that hydrodynamic interactions between MCCs limit their rate of work so that they best shear the tissue at a finite but low area coverage, a result that mirrors findings for other sparse distributions such as cell receptors and leaf stomata.
Fichier principal
Vignette du fichier
PhysRevLett.127.198102.pdf (791.49 Ko) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

hal-04231230 , version 1 (09-07-2024)

Licence

Identifiers

Cite

Francesco Boselli, Jerome Jullien, Eric Lauga, Raymond Goldstein. Fluid Mechanics of Mosaic Ciliated Tissues. Physical Review Letters, 2021, 127 (19), pp.198102. ⟨10.1103/PhysRevLett.127.198102⟩. ⟨hal-04231230⟩
10 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More