Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance - Nantes Université
Article Dans Une Revue Mycoses Année : 2021

Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance

Débora Castelo‐branco
  • Fonction : Auteur
Shawn Lockhart
Yee‐chun Chen
  • Fonction : Auteur
Daniel Santos
Ferry Hagen
  • Fonction : Auteur
Nichola Hawkins
  • Fonction : Auteur
Jacques Meis
  • Fonction : Auteur
Marcos Rocha
  • Fonction : Auteur
José Sidrim
  • Fonction : Auteur
Maiken Arendrup
  • Fonction : Auteur

Résumé

Candida and Cryptococcus affect millions of people yearly, being responsible for a wide array of clinical presentations, including life-threatening diseases. Interestingly, most human pathogenic yeasts are not restricted to the clinical setting, as they are also ubiquitous in the environment. Recent studies raise concern regarding the potential impact of agricultural use of azoles on resistance to medical antifungals in yeasts, as previously outlined with Aspergillus fumigatus. Thus, we undertook a narrative review of the literature and provide lines of evidence suggesting that an alternative, environmental route of azole resistance, may develop in pathogenic yeasts, in addition to patient route. However, it warrants sound evidence to support that pathogenic yeasts cross border between plants, animals and humans and that environmental reservoirs may contribute to azole resistance in Candida or other yeasts for humans. As these possibilities could concern public health, we propose a road map for future studies under the One Health perspective.

Dates et versions

hal-03630279 , version 1 (25-08-2022)

Identifiants

Citer

Débora Castelo‐branco, Shawn Lockhart, Yee‐chun Chen, Daniel Santos, Ferry Hagen, et al.. Collateral consequences of agricultural fungicides on pathogenic yeasts: A One Health perspective to tackle azole resistance. Mycoses, 2021, 65, pp.303 - 311. ⟨10.1111/myc.13404⟩. ⟨hal-03630279⟩
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