Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction? - Nantes Université Access content directly
Journal Articles Neuropsychology Year : 2015

Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction?

Sébastien Barbarot
Valérie Charbonnier
  • Function : Author
Marie Gayet-Delacroix
  • Function : Author
Jean-François Stalder
  • Function : Author
Jean-Luc Roulin
  • Function : Author

Abstract

It was hypothesized that neuropsychological impairments in children with neurofibromatosis type I (NF1) are associated with brain areas of increased T2-weighted signal intensity on MRI. Systematic and extensive examination of this hypothesis remains however scarce, particularly regarding executive dysfunction whereas hyperintensities are located preferentially in frontal-sub-cortical networks. In this study, we compared the executive functioning profile with characteristics of brain hyperintensities in children with NF1.
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hal-03329608 , version 1 (31-08-2021)

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Arnaud Roy, Didier Le Gall, Sébastien Barbarot, Valérie Charbonnier, Marie Gayet-Delacroix, et al.. Examining the frontal subcortical brain vulnerability hypothesis in children with neurofibromatosis type 1: are T2-weighted hyperintensities related to executive dysfunction?. Neuropsychology, 2015, 29 (3), pp.473-484. ⟨10.1037/neu0000151⟩. ⟨hal-03329608⟩
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