Vitamin D and chronic diseases : the current state of the art - Nantes Université Access content directly
Journal Articles Archives of Toxicology Year : 2017

Vitamin D and chronic diseases : the current state of the art

Giovanna Muscogiuri
  • Function : Author
Barbara Altieri
  • Function : Author
Giancarlo Balercia
H. B. Pal
  • Function : Author
Barbara J. Boucher
  • Function : Author
John J. Cannell
  • Function : Author
Carlo Foresta
  • Function : Author
Martin R. Grübler
  • Function : Author
Kalliopi Kotsa
  • Function : Author
Luca Mascitelli
  • Function : Author
Francesco Orio
  • Function : Author
Giacomo Tirabassi
  • Function : Author
Annamaria Colao
  • Function : Author


The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document’s topic that was subjected to voting by all experts as “yes” (agreement with the content and/or wording) or “no” (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with \textless25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.
No file

Dates and versions

hal-03287641 , version 1 (15-07-2021)



Giovanna Muscogiuri, Barbara Altieri, Cédric Annweiler, Giancarlo Balercia, H. B. Pal, et al.. Vitamin D and chronic diseases : the current state of the art. Archives of Toxicology, 2017, 91 (1), pp.97-107. ⟨10.1007/s00204-016-1804-x⟩. ⟨hal-03287641⟩
26 View
0 Download



Gmail Facebook X LinkedIn More