%0 Journal Article %T Arginine Vasopressin and Posterior Reversible Encephalopathy Syndrome Pathophysiology: the Missing Link? %+ Laboratoire de Biochimie et de Biologie Moléculaire %+ Laboratoire de biochimie et biologie moléculaire, CHRU Tours %+ MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE) %+ CHU Trousseau [Tours] %+ Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation (IPPRITT) %+ Laboratoire de Biochimie et Biologie Moléculaire [Tours] %+ Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR) %+ Service de réanimation (CHRU Tours) %A Largeau, Bérenger %A Le Tilly, Olivier %A Sautenet, Bénédicte %A Salmon Gandonnière, Charlotte %A Barin-Le Guellec, Chantal %A Ehrmann, Stephan %< avec comité de lecture %@ 0893-7648 %J Molecular Neurobiology %I Humana Press %V 56 %N 10 %P 6792-6806 %8 2019-10 %D 2019 %R 10.1007/s12035-019-1553-y %K Antidiuretic hormone %K Blood-brain barrier %K Hypertensive encephalopathy %K Leukoencephalopathy syndrome %K Neurological adverse drug reactions. %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological entity characterized by a typical brain edema. Its pathogenesis is still debated through hypoperfusion and hyperperfusion theories, which have many limitations. As PRES occurs almost exclusively in clinical situations with arginine vasopressin (AVP) hypersecretion, such as eclampsia and sepsis, we hypothesize that AVP plays a central pathophysiologic role. In this review, we discuss the genesis of PRES and its symptoms through this novel approach. We theorize that AVP axis stimulation precipitates PRES development through an increase in AVP secretion or AVP receptor density. Activation of vasopressin V1a receptors leads to cerebral vasoconstriction, causing endothelial dysfunction and cerebral ischemia. This promotes cytotoxic edema through hydromineral transglial flux dysfunction and may increase endothelial permeability, leading to subsequent vasogenic brain edema. If our hypothesis is confirmed, it opens new perspectives for better patient monitoring and therapies targeting the AVP axis in PRES. %G English %L hal-03183366 %U https://nantes-universite.hal.science/hal-03183366 %~ UNILIM %~ UNIV-NANTES %~ UNIV-TOURS %~ GEIST %~ IPPRITT %~ SPHERE_HEALTH_RESEARCH %~ PT %~ OMEGAHEALTH %~ NANTES-UNIVERSITE %~ UNIV-NANTES-AV2022 %~ CEPR %~ TEST3-HALCNRS %~ LABCIS