Transgenic mouse model Muscle Centronuclear myopathy Motoneuron Mouse model Gene editing PacBio Gene Therapy Myotonic dystrophy mouse models MBNL Therapy Trinucleotide Repeat Expansion DMSXL mice Expression Aging Heart failure CTG repeats Cell penetrating peptide Central nervous system Desmin Astrocyte Duchenne muscular dystrophy Autophagy Dilated cardiomyopathy Muscular dystrophy RNA biology KNOCKOUT MICE Knockout Endurance training CMS DMPK Glutamate Acute coronary syndrome Myotonic Dystrophy Dystrophin GSK3␤ Acetylcholinesterase knockout mouse Exercice Fibrosis DM1 Quantitative microdialysis CRISPR/Cas9 Hypoxia Brain Myostatin Glucocorticoid-receptor RNA interference Diaphragm ACETYLCHOLINESTERASE GABA Humans Neuron Acetylcholinesterase deficiency Intermediate filament Cytoskeleton Astrocytes Glucocorticoids Transgenic mouse AAV Animals Cell culture model Myotonic dystrophy Antisense oligonucleotides Oligodendrocyte In vivo ARN Myotonic Dystrophy Type 1 Thérapie génique Genotype phenotype correlation Long read sequencing PCR CONGENITAL MYATHENIC SYNDROME Dystrophie Myotonique Antisense oligonucleotide Heart Myelin Oligodendrocytes Alternative splicing Mice Skeletal muscle Brain dysfunction RNA splicing Transcriptomics Cell model Myotonic Dystrophy type 1 Maximal force CTG repeat contractions Dynamin 2 Dystrophie myotonique CTG repeat instability Gene therapy BIOLOGIE MOLECULAIRE Trinucleotide repeat expansion Exercise Male CRISPRi Cardiac muscle Glial cells Mouse models Myotonic dystrophy type 1